Developing Novel HIV-1 Vaccine Immunogens
With >36 million people infected and almost 2 million new infections in 2016, the need for a prophylactic HIV-1 vaccine is as urgent as ever. Approximately 20-30% of HIV-1 infected individuals...
View ArticleDesign and Testing of Novel Vaccines Against Epstein-Barr Virus
Epstein-Barr virus (EBV) is one of the most common human viruses. It is a causative agent of infectious mononucleosis and is associated with ~200 000 new cases of cancer and ~140,000 deaths annually....
View ArticleDeveloping Immunotherapy Approaches to Target Surface Proteins on Virally...
Many EBV-associated cancers express virally-encoded transmembrane proteins. Two such proteins Latent Membrane Protein1 (LMP1) and Latent Membrane Protein 2 (LMP2) that play roles in oncogenesis. Both...
View ArticleAdvanced development and clinical evaluation of a synthetic intranasal...
This project proposes to optimize, manufacture, and clinically evaluate an intranasally delivered prophylactic Entamoeba histolytica vaccine (NIAID Category B pathogen) containing adjuvant. The...
View ArticleExpansion and targeted maturation of germline HIV-1 bNAb-associated BCRs
The objective of this grant is to investigate the relationship between the relative frequencies of target B cells and the binding affinity of the immunogen with the expansion and maturation of the...
View ArticleNeutralizing and non-neutralizing antibody effector functions in HIV infected...
This project aims to compare the frequency of broadly neutralizing B cell receptor progenitors between adults and young children.Active Dates 01/01/2019 to 12/31/2024Faculty Involved Leo...
View ArticleImmunology of Merkel cell carcinoma
In the context of a UW-Fred Hutchinson P01 grant from the National Cancer Institute, the Project headed by the Koelle lab will investigate T cell recognition of Merkel cell polyoma virus, a...
View ArticleTissue resident memory response to VZV infection
This NIH R01 lab science project determines the signature of VZV-specific T cells left in skin after recovery from shingles and determines if the recombinant zoster vaccine leads to an increase in...
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Leslie Goo
Affiliate Assistant Professor, Global HealthBiography Dr. Leslie Goo studies the immune response to flaviviruses, which are transmitted to humans by mosquitoes and ticks and are significant threats to...
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Victor Omballa
Clinical Instructor, Global HealthUniversity of WashingtonBox 357965, WAUnited StatesPhone Number: Country Affiliations KenyaFax: Email: omballa@uw.eduPublications Hunsperger E et al., 2020. Zika virus...
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